Chronological Age Deferment refers to the clinical objective of implementing strategies that slow the accrual of biological damage and functional decline typically associated with the passage of chronological time. This is a practical goal in longevity medicine, focusing on maintaining physiological function and tissue integrity at a level characteristic of a younger chronological age. It aims to extend healthspan by mitigating age-related hormonal and cellular degradation.
Origin
The concept is an extension of traditional gerontology and preventive medicine, shifting the focus from simply increasing lifespan to improving the quality of life across the years lived. ‘Deferment’ highlights the proactive clinical effort to push back the onset of age-related diseases and functional limitations. It is deeply intertwined with the study of hormonal changes, like somatopause and andropause, and their mitigation.
Mechanism
Deferment strategies often involve optimizing key hormonal axes, enhancing cellular repair mechanisms like autophagy, and reducing chronic low-grade inflammation, or inflammaging. By maintaining youthful levels of growth factors and sex hormones, and supporting metabolic flexibility, the body’s inherent repair and regeneration capabilities are preserved. This action functionally postpones the manifestation of aging phenotypes in various organ systems.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.