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Chronodisruption Reversal

Meaning

Chronodisruption reversal is the clinical process of actively correcting and resynchronizing the body’s internal circadian rhythms, or biological clocks, which have become misaligned due to environmental or behavioral factors. This therapeutic goal addresses the physiological state of chronodisruption, where the central pacemaker and peripheral tissue clocks are out of phase with the external light-dark cycle and with each other. Successful reversal is critical for restoring optimal endocrine signaling, metabolic function, and sleep architecture.