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Chronobiological Signaling Fidelity

Meaning

Chronobiological Signaling Fidelity describes the accuracy and robustness with which internal biological clocks, particularly the suprachiasmatic nucleus (SCN), transmit timing cues to peripheral endocrine tissues. High fidelity ensures that hormone pulses, such as those from the HPA axis or the gonadal axis, occur precisely according to the 24-hour cycle. Loss of fidelity results in desynchronization, leading to impaired metabolic and restorative functions. This concept is central to understanding circadian misalignment.