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Chrono-Calibration

Meaning

Chrono-Calibration is the precise clinical practice of timing external inputs, such as medication, nutrient intake, or specific light exposure, to align optimally with an individual’s endogenous circadian rhythms. This strategy aims to synchronize internal biological clocks with external environmental cues, thereby enhancing the efficacy of interventions and improving overall physiological function. The process focuses on regulating the master pacemaker in the suprachiasmatic nucleus and the peripheral cellular clocks. Achieving this calibration is crucial for optimizing hormone secretion, sleep quality, and metabolic processes.