Chronically elevated hunger signals refer to a persistent, pathological increase in the neuroendocrine stimuli that drive appetite and food-seeking behavior, extending beyond the physiological need for energy. This state reflects a dysregulation in the intricate hormonal communication network responsible for energy balance and satiety, leading to a continuous sensation of hunger. Clinically, this persistent signaling contributes significantly to sustained positive energy balance and subsequent weight gain or resistance to weight loss interventions. It represents a functional failure in the body’s internal appetite thermostat.
Origin
This descriptive term originates from the clinical observation of patients struggling with persistent hunger despite adequate caloric intake, linking the psychological sensation of hunger to underlying chronic physiological dysfunction. The concept integrates classical endocrinology, which identified key hunger hormones, with neuroscience, which maps the central processing of these signals in the hypothalamus and brainstem. It highlights the chronic nature of metabolic dysregulation.
Mechanism
The mechanism involves the sustained, high-level secretion of orexigenic (appetite-stimulating) peptides, such as ghrelin, often coupled with reduced sensitivity or inadequate post-meal release of anorexigenic (satiety-inducing) hormones like leptin, GLP-1, and PYY. This hormonal imbalance creates a potent, ongoing drive for consumption that overrides voluntary control. The continuous stimulation of neuropeptide Y and Agouti-related peptide neurons in the arcuate nucleus of the hypothalamus perpetuates the cycle of elevated hunger.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.