What is the Origin of Chronic Stress Sequelae?

The term is derived from the medical Latin word sequela, meaning a condition resulting from a previous disease or injury, combined with the established clinical understanding of chronic stress physiology. This concept formalizes the cumulative damage, or allostatic load, incurred by a system under sustained, unremitting pressure.

What is the Mechanism of Chronic Stress Sequelae?

The mechanism involves the chronic overexposure to glucocorticoids, leading to a down-regulation and desensitization of glucocorticoid receptors in the central nervous system, thereby impairing the crucial negative feedback loop of the HPA axis. This hormonal dysregulation also drives chronic low-grade inflammation, suppresses the functional capacity of the thyroid axis, and profoundly alters the appropriate diurnal rhythm of cortisol, ultimately leading to widespread systemic exhaustion and pathology.

Chronic Stress Sequelae ∞ Area

Chronic Stress Sequelae

Meaning

Chronic Stress Sequelae are the long-term, pathological consequences that result from the sustained, maladaptive activation of the body’s stress response systems, particularly the Hypothalamic-Pituitary-Adrenal (HPA) axis and the sympathetic nervous system. These sequelae manifest as a spectrum of systemic dysfunctions, including immune dysregulation, metabolic syndrome, and persistent, complex hormonal imbalances. Clinically, recognizing these downstream effects is essential for comprehensive and effective management.