What is the Origin of Chronic Inflammatory State Reversal?

The concept is a therapeutic extension of the understanding of chronic inflammation, which has been recognized as a key driver of disease since the mid-20th century. "Reversal" implies a clinical goal of active resolution, moving beyond simple suppression of symptoms. It is closely linked to the resolution phase of inflammation, a specific physiological process.

What is the Mechanism of Chronic Inflammatory State Reversal?

Reversal is accomplished by targeting the underlying triggers of inflammation, such as gut dysbiosis, chronic stress, or adipocyte-driven cytokine release. Key mechanisms involve enhancing the production of specialized pro-resolving mediators (SPMs), suppressing the activation of the NF-kappa B pathway, and normalizing the hypothalamic-pituitary-adrenal (HPA) axis function, which is often hyper-activated by chronic stress. Successful reversal reduces systemic burden and improves cellular sensitivity to metabolic hormones like insulin and leptin.

Chronic Inflammatory State Reversal ∞ Area

Chronic Inflammatory State Reversal

Meaning

Chronic Inflammatory State Reversal refers to the clinical strategy of actively resolving persistent, low-grade systemic inflammation, which is often subclinical but detrimental to long-term health. This sustained immune activation, characterized by elevated inflammatory markers like C-reactive protein and specific cytokines, is a root cause of many age-related and metabolic dysfunctions. Achieving reversal involves shifting the body’s immune balance from a pro-inflammatory state back to a quiescent, anti-inflammatory, and pro-resolving one. This restoration is crucial for preventing tissue damage and optimizing hormonal signaling pathways.