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Chronic Inflammation Setpoint Control

Meaning

Chronic Inflammation Setpoint Control refers to the physiological regulatory mechanism that establishes and maintains an individual’s baseline level of systemic, low-grade inflammation. This setpoint is influenced by genetic predisposition, lifestyle factors, hormonal balance, and the integrity of the gut barrier. A perpetually elevated setpoint is a foundational driver of numerous age-related and metabolic disorders, including insulin resistance and cardiovascular disease, significantly impacting hormonal signaling. Clinical efforts aim to precisely modulate this setpoint downward to promote health and longevity.