What is the Origin of Chronic Inflammation Reversal?

This term is rooted in immunology and pathology, where the distinction between acute, protective inflammation and chronic, destructive inflammation is fundamental. 'Reversal' emphasizes an active, measurable therapeutic endpoint, distinguishing it from mere symptom management.

What is the Mechanism of Chronic Inflammation Reversal?

Reversal is achieved by addressing primary drivers such as visceral adiposity, gut dysbiosis, chronic infection, or persistent oxidative stress. The mechanism involves shifting the immune cell phenotype from pro-inflammatory (e.g., Th1/Th17 dominance) to a pro-resolving state, often mediated by specialized pro-resolving mediators (SPMs) and a reduction in pattern recognition receptor activation. This fundamental shift allows tissues to enter a phase of repair and regeneration.

Chronic Inflammation Reversal

Meaning

The therapeutic strategy and successful outcome of resolving persistent, low-grade, systemic inflammatory signaling that underlies many chronic diseases and accelerates biological aging. This process involves identifying and eliminating the root causes of the immune system’s sustained activation, leading to a measurable reduction in pro-inflammatory biomarkers. Achieving reversal is a cornerstone of longevity medicine, significantly improving long-term health and reducing all-cause morbidity.