Skip to main content

Chronic Inflammation Resolution

Meaning

Chronic Inflammation Resolution is the active, programmed physiological process that terminates the inflammatory response, restores tissue homeostasis, and prevents the transition from acute to persistent, low-grade systemic inflammation. This is not merely the passive cessation of inflammatory signals but an active, complex biological program involving specialized pro-resolving mediators (SPMs). Failure in this resolution phase is a fundamental driver of many chronic diseases, including metabolic syndrome and age-related hormonal decline. Effective resolution is paramount for preserving cellular function and maintaining long-term health.