What is the Origin of Chronic Inflammation Modulation?

The understanding of chronic, sterile inflammation, or "inflammaging," as a key mechanism of aging and disease pathology emerged from modern immunology and gerontology research. Modulation emphasizes the goal of controlled adjustment rather than simple suppression, recognizing the immune system's dual role in both defense and repair. This concept formalizes therapeutic efforts to resolve underlying inflammatory triggers.

What is the Mechanism of Chronic Inflammation Modulation?

Modulation is achieved by identifying and removing inflammatory stimuli, such as gut dysbiosis, food sensitivities, or excessive adipose tissue, which is a major source of pro-inflammatory cytokines. Targeted interventions utilize specific nutrients, peptides, and pharmacological agents to inhibit NF-κB signaling and enhance the production of specialized pro-resolving mediators (SPMs). This mechanism restores immune balance and promotes a regenerative tissue environment.

Chronic Inflammation Modulation

Meaning

Chronic Inflammation Modulation is the clinical strategy of deliberately regulating persistent, low-grade systemic inflammation, which is a primary driver of numerous age-related diseases and hormonal dysregulation. This approach aims to transition the body from a pro-inflammatory state to a state of resolution and tissue repair. Successful modulation is central to improving metabolic health and overall longevity.

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Chronic Inflammation Modulation

Meaning

Origin

Mechanism

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