What is the Origin of Chronic Inflammation Markers?

This concept emerged from the recognition that chronic, sterile inflammation, often termed "inflammaging," is a key driver of biological decline and is intrinsically linked to metabolic and endocrine dysfunction. The measurement of these specific markers transitioned from purely infectious disease diagnostics to a central component of preventative and functional health assessments. This clinical practice acknowledges inflammation as a systemic, treatable pathology.

What is the Mechanism of Chronic Inflammation Markers?

Sustained exposure to stressors, such as visceral adiposity, gut dysbiosis, or chronic stress, leads to the continuous activation of innate immune pathways, like the NF-κB cascade. This activation results in the low-level, continuous production of pro-inflammatory cytokines, which then drive the liver to produce acute-phase reactants like hs-CRP. These mediators interfere with hormone receptor sensitivity and accelerate tissue damage, creating a cycle of dysregulation.

Chronic Inflammation Markers

Meaning

A panel of measurable biochemical indicators present in blood or tissue that reflect a state of persistent, low-grade systemic inflammatory activity, distinct from acute, localized inflammation. Clinically relevant markers include high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and fibrinogen, which serve as objective proxies for underlying metabolic and immune stress. Elevated levels are strongly correlated with increased risk for numerous age-related and hormonal dysfunctions.