What is the Origin of Chronic Inflammation Biomarkers?

The term originates from the convergence of immunology and clinical laboratory medicine, utilizing measurable molecules to characterize the often-silent process of chronic, systemic inflammation. The concept recognizes that inflammation is not exclusively an acute response to injury but also a low-level, continuous driver of chronic pathology. Biomarker assessment provides an objective, measurable link between adverse lifestyle factors and internal inflammatory status.

What is the Mechanism of Chronic Inflammation Biomarkers?

Persistent exposure to metabolic dysfunction, chronic infection, or visceral adiposity triggers the release of pro-inflammatory cytokines from immune cells and fat tissue. These cytokines then stimulate the liver to produce acute-phase reactants, such as hs-CRP, which circulate throughout the body. The underlying mechanism involves the sustained activation of inflammatory signaling pathways, leading to continuous, low-level tissue destruction and impaired cellular communication across various organ systems.

Chronic Inflammation Biomarkers ∞ Area

Chronic Inflammation Biomarkers

Meaning

Chronic Inflammation Biomarkers are quantifiable molecular indicators, typically measured in serum or saliva, that reflect a persistent, low-grade activation of the innate immune system within the body. These markers, which include high-sensitivity C-reactive protein (hs-CRP), Interleukin-6 (IL-6), and fibrinogen, signal underlying systemic stress and tissue distress. Clinically, elevated levels are strongly associated with an increased risk for numerous age-related pathologies, including cardiovascular disease and cognitive decline.