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Chronic Illness Physiology

Meaning

Chronic Illness Physiology refers to the long-term, pathological alterations in human biological function that underpin persistent, non-communicable diseases such as metabolic syndrome, type 2 diabetes, and certain autoimmune conditions. This physiological state is characterized by chronic, low-grade inflammation, sustained allostatic load on the endocrine and nervous systems, and progressive cellular dysfunction. Understanding this altered homeostasis is crucial for clinical intervention, as it moves beyond symptom management to address the core biological drivers of sustained disease. It often involves a state of persistent metabolic and hormonal dysregulation.