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Chronic Hypercortisolism Pathology

Meaning

This clinical term describes the state of sustained, pathological elevation of circulating cortisol levels, leading to a cascade of adverse systemic health consequences. Prolonged exposure to high glucocorticoids disrupts normal physiological processes, moving beyond the acute stress response into a disease state. The pathology encompasses a spectrum of metabolic, immune, cardiovascular, and psychological dysfunctions. This condition is often associated with chronic, unmanaged stress or specific endocrine tumors, necessitating precise clinical intervention.