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Chronic Fatigue Syndrome Endocrinology

Meaning

Chronic Fatigue Syndrome Endocrinology refers to the study and clinical assessment of hormonal and neuroendocrine system abnormalities observed in individuals diagnosed with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Research in this area consistently reveals subtle yet significant alterations in the hypothalamic-pituitary-adrenal (HPA) axis, including low basal cortisol levels and a blunted cortisol response to stress. This endocrine profile suggests a state of central nervous system dysregulation, rather than peripheral glandular failure, which contributes significantly to the characteristic fatigue, pain, and immune dysfunction of the syndrome. Understanding this hormonal signature is key to developing targeted, effective management strategies.