What is the Origin of Chronic Fatigue Pathophysiology?

The term combines "chronic fatigue," a long-recognized clinical complaint, with "pathophysiology," which is the functional changes associated with disease or injury. Its modern application emerged as clinical research sought concrete, measurable biological explanations for this complex, systemic condition.

What is the Mechanism of Chronic Fatigue Pathophysiology?

The mechanism often involves a combination of mitochondrial dysfunction, which severely impairs cellular energy production (ATP), and chronic activation of the immune system, leading to elevated systemic inflammation. Furthermore, dysregulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis is frequently observed, which disrupts the normal cortisol rhythm and the body's essential ability to manage stress and maintain energy balance.

Chronic Fatigue Pathophysiology ∞ Area

Chronic Fatigue Pathophysiology

Meaning

Chronic Fatigue Pathophysiology is the scientific study of the underlying biological and physiological mechanisms that drive the persistent, debilitating exhaustion characteristic of Chronic Fatigue Syndrome (CFS) or Myalgic Encephalomyelitis (ME/CFS). It focuses on identifying measurable dysfunctions in the body’s systems, moving beyond a purely symptomatic diagnosis. Key areas of investigation include energy production, immune dysregulation, and neuroendocrine axis disturbances.