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Chronic Fatigue Mechanisms

Meaning

Chronic Fatigue Mechanisms are the diverse, interconnected physiological and biochemical dysfunctions that underlie the persistent, debilitating, and unexplained fatigue characteristic of chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME/CFS). These mechanisms often involve a complex interplay of immune system dysregulation, persistent low-grade inflammation, mitochondrial dysfunction leading to impaired energy production, and disturbances in the Hypothalamic-Pituitary-Adrenal (HPA) axis. Understanding these pathways is crucial for developing targeted, effective clinical interventions beyond symptomatic management. The condition represents a profound failure of the body’s homeostatic and energy-generating systems.