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Cholesterol Loading Variance

Meaning

Cholesterol Loading Variance describes the dynamic fluctuation or heterogeneity in the amount of cholesterol carried within individual lipoprotein particles, particularly those in the Low-Density Lipoprotein (LDL) spectrum. This variance is not a measure of total cholesterol mass but rather an indicator of the compositional changes within the circulating lipoprotein pool. A high variance, often associated with smaller, denser LDL particles, suggests an increased vulnerability to oxidative stress and impaired cellular cholesterol clearance mechanisms. This metric offers insight into the metabolic quality of the lipoprotein profile.