Question 1

What is the Meaning of Chitosan?

Accepted Answer

Chitosan is a linear polysaccharide derived from the deacetylation of chitin, which is the main component of crustacean exoskeletons and fungal cell walls. In a clinical context, it is recognized as a biocompatible, biodegradable, and non-toxic polymer. Its unique cationic nature, meaning it carries a positive charge, makes it a valuable excipient and functional ingredient in advanced drug delivery systems, particularly within the hormonal health domain.

Question 2

What is the Origin of Chitosan?

Accepted Answer

The term Chitosan is derived from its precursor, chitin, a compound first isolated in the 19th century. Its utility in biomedical applications, however, became prominent in the late 20th century due to its advantageous properties, including mucoadhesion and capacity for complexing with negatively charged biological molecules. This natural origin provides a foundation for its use in bio-friendly pharmaceutical formulations.

Question 3

What is the Mechanism of Chitosan?

Accepted Answer

Chitosan's mechanism in drug delivery primarily involves its mucoadhesive property, allowing it to adhere to mucosal surfaces, such as those in the nasal or vaginal tracts, enhancing local retention and absorption. Its positive charge also allows it to interact with the negatively charged cell membranes, transiently opening tight junctions between epithelial cells. This action facilitates the paracellular transport of co-administered hormones or peptides, improving their systemic bioavailability.

Chitosan

Meaning

Origin

Mechanism

How Do Oral Peptide Formulations Overcome Digestive Barriers?

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