The comprehensive, high-resolution analysis of the full spectrum of small molecules, or metabolites, present in a biological sample, such as blood or urine, to generate a unique metabolic fingerprint. This mapping reveals subtle, functional changes in biochemical pathways that precede traditional diagnostic shifts, offering a deep understanding of an individual’s current physiological and hormonal status. It is a key tool in precision endocrinology.
Origin
Grounded in the scientific discipline of metabolomics, which systematically studies the chemical processes involving metabolites. The term highlights the clinical application of this technology to move beyond single-analyte testing and visualize the entire functional output of the body’s systems. This advanced technique provides a functional view of biochemistry.
Mechanism
Operates by identifying and quantifying hundreds to thousands of endogenous and exogenous compounds, providing a dynamic readout of metabolic flux. The resulting signature can reveal deficiencies in cofactors, shifts in neurotransmitter metabolism, or early indicators of insulin resistance and hormonal dysregulation. This functional data guides highly specific, targeted therapeutic interventions, maximizing treatment precision.
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