What is the Origin of Chemical Signalling?

The term is foundational to modern physiology and endocrinology, deriving from the understanding that complex organisms require sophisticated methods for coordinating distant cellular activities. The concept of hormones as chemical messengers was established in the early 20th century, with 'chemical' denoting the nature of the messenger and 'signalling' describing the transmission of information. It represents a core principle of cell biology and pharmacology.

What is the Mechanism of Chemical Signalling?

The process begins when a signaling molecule is released, travels to a target cell, and binds specifically to a cognate receptor, which may be located on the cell surface or intracellularly. This binding event initiates a cascade of intracellular events—a signal transduction pathway—that ultimately alters gene expression, enzyme activity, or cellular behavior. Disruptions to this delicate mechanism, often caused by environmental chemicals, can lead to hormonal resistance or dysregulation.

Chemical Signalling

Meaning

Chemical Signalling is the fundamental biological process by which cells communicate with one another using chemical messengers, such as hormones, neurotransmitters, cytokines, and growth factors. This intricate system governs virtually all physiological functions, including metabolism, reproduction, mood, and stress response. In the context of hormonal health, it specifically refers to the endocrine and paracrine transmission of information necessary for maintaining systemic biochemical regulation and homeostasis.