The complex, interconnected systems of molecular communication that govern all physiological processes within the body. These networks involve hormones, neurotransmitters, cytokines, and other signaling molecules transmitting precise information between cells, tissues, and organs. Their accurate and timely coordination is essential for maintaining systemic homeostasis and adaptive function in response to environmental changes.
Origin
The concept evolves from classical endocrinology and neurobiology, where individual hormones and neurotransmitters were studied in isolation. The term ‘networks’ acknowledges the modern understanding of cross-talk and redundancy between these diverse chemical messengers. This perspective emphasizes the integrated nature of the endocrine, nervous, and immune systems as a single regulatory unit.
Mechanism
Signaling molecules bind to specific cellular receptors, initiating a cascade of intracellular events known as signal transduction pathways. This process ultimately modulates gene expression, enzyme activity, or cellular behavior, resulting in a physiological response. The efficiency and accuracy of these networks are highly sensitive to nutritional status, environmental toxins, and chronic stress, which can lead to endocrine disruption and impaired cellular communication.
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