The Chemical Lexicon refers to the entire repertoire of signaling molecules, including hormones, neurotransmitters, cytokines, and metabolites, that the body utilizes for communication and regulation. It is essentially the internal language of the human physiological system, conveying instructions between cells, tissues, and organs. A well-functioning lexicon ensures precise and timely biological responses to internal and external stimuli, maintaining systemic harmony. Imbalances or “miscommunications” within this lexicon are often the root cause of complex chronic health issues.
Origin
This term is a metaphor, combining “chemical,” relating to the molecular components of life, with “lexicon,” a word for the vocabulary of a language. It is used in clinical and systems biology to emphasize the informational and communicative nature of biochemicals. The concept highlights that physiological regulation is not merely a series of isolated reactions but a complex, integrated dialogue.
Mechanism
Signaling molecules are synthesized in specific glands or cells and then travel through the circulation to target receptors on distant cells. The binding of a molecule to its receptor initiates a cascade of intracellular events, translating the chemical signal into a biological action. This continuous, complex exchange of chemical messages governs everything from metabolism and mood to immune response and reproductive function.
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