Chemical Information Theory, in the context of human physiology, refers to the concept that chemical signals—like hormones, neurotransmitters, and cytokines—act as critical units of information governing cellular and systemic function. This framework posits that health and disease are fundamentally linked to the fidelity, amplitude, and timing of these chemical communication networks. The theory highlights the importance of precise signaling for maintaining biological order and homeostasis.
Origin
This term is an application of general Information Theory, originally developed in mathematics and electrical engineering, adapted to the complex chemical signaling of biological systems. It finds its roots in molecular biology and endocrinology, where hormones are explicitly recognized as messengers carrying regulatory instructions. The application emphasizes the signal-to-noise ratio and the interpretation of chemical data by cellular receptors.
Mechanism
The mechanism involves the synthesis, release, transport, receptor binding, and subsequent cellular transduction of chemical messengers. The theory focuses on how the concentration and structure of a signaling molecule convey specific instructions to target cells. Disruption of this chemical information flow, whether through receptor desensitization, metabolic clearance issues, or incorrect precursor availability, results in systemic dysfunction and pathology.
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