The hierarchical organization and interaction dynamics among endogenous signaling molecules, primarily hormones and neurotransmitters, that govern overall physiological function. This structure dictates the sequence and intensity of biological responses across various organ systems in a coordinated manner. Understanding this architecture is fundamental to interpreting endocrine regulation.
Origin
This phrase borrows from information theory and organizational science, applying its principles to the complex interplay of the endocrine and nervous systems. It conceptualizes the chemical messengers as a structured, directive hierarchy rather than a collection of independent signals.
Mechanism
The structure functions via receptor binding specificity and subsequent second messenger cascades within target cells following ligand attachment. For example, the hypothalamic-pituitary axis forms the apex, issuing chemical commands that cascade down to peripheral tissues via lower-tier hormones. Feedback loops provide essential regulatory checks, ensuring the intensity of the chemical signal remains appropriate for the required physiological output.
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