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Channelopathy

Meaning

A Channelopathy is a class of diseases resulting from the malfunction of ion channels, which are pore-forming protein structures situated in the plasma membranes of cells that regulate the flow of ions. These disorders disrupt the normal electrical signaling and ion homeostasis crucial for proper cellular function, particularly in excitable tissues like muscle, nerve, and endocrine glands. In the realm of hormonal health, channelopathies are clinically significant as they can profoundly affect the secretion of hormones, such as in certain forms of primary aldosteronism linked to potassium or calcium channel defects. Recognizing a channelopathy allows for targeted therapeutic interventions aimed at restoring normal ion flow.