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CGRP Inhibitors

Meaning

CGRP Inhibitors are a class of pharmacological agents specifically designed to target the calcitonin gene-related peptide pathway, a potent neuropeptide implicated in nociception and vasodilation. These medications are primarily used in the prophylactic and acute treatment of severe migraine headaches and cluster headaches. They function by either blocking the CGRP receptor (small-molecule gepants) or by binding directly to the CGRP ligand itself (monoclonal antibodies). Clinical application has shown significant efficacy in reducing migraine frequency and severity, offering a targeted, mechanism-specific approach to pain management.