A pharmaceutical preparation containing biologically active low-molecular-weight peptides and amino acids that are purported to mimic the effects of endogenous neurotrophic factors in the brain. The ‘Neurorestorative’ aspect refers to its clinical application in promoting recovery and repair following acute or chronic neurological damage, such as stroke or neurodegenerative conditions. It is clinically utilized to support neural regeneration and functional improvement.
Origin
‘Cerebrolysin’ is a proprietary name for a peptide-based drug, while ‘Neurorestorative’ combines ‘neuro’ (nerve) and ‘restorative’ (having the ability to restore health or strength). The therapeutic concept originates from the observation that certain brain-derived peptides can facilitate the brain’s intrinsic repair mechanisms. This led to the development of this specific therapeutic agent.
Mechanism
The constituent peptides are believed to cross the blood-brain barrier and stimulate neuronal survival pathways, enhance synaptic plasticity, and promote neurogenesis in compromised brain regions. Specifically, it is thought to modulate the activity of various neurotrophic factors, including BDNF and NGF, which collectively support the structural and functional integrity of neuronal networks. This multifaceted action aims to stabilize cellular metabolism and reduce excitotoxicity.
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