What is the Origin of Central Fatigue Neurobiology?

This field draws its name from the central nervous system, encompassing the brain and spinal cord, and the clinical symptom of fatigue. The term evolved from exercise physiology to encompass broader states of chronic exhaustion, acknowledging that fatigue is fundamentally a brain-regulated protective mechanism. Clinical endocrinology recognizes the significant interplay between hormonal axes, like the HPA axis and thyroid function, and these central fatigue pathways.

What is the Mechanism of Central Fatigue Neurobiology?

The underlying mechanism involves alterations in key neurotransmitter systems, particularly the balance between excitatory and inhibitory signals in the brain, often including the ratio of serotonin to dopamine. Systemic factors, such as chronic inflammation, can also contribute by allowing pro-inflammatory cytokines to cross the blood-brain barrier. These mediators affect neuronal signaling, leading to reduced central motor drive and impaired executive function, thus manifesting as pervasive, non-restorative fatigue.

Central Fatigue Neurobiology ∞ Area

Central Fatigue Neurobiology

Meaning

Central Fatigue Neurobiology is the specialized study of the neurological and biochemical changes within the central nervous system that primarily contribute to the subjective feeling of profound, overwhelming tiredness. This type of exhaustion is distinct from peripheral muscle fatigue and involves a measurable reduction in the central drive to maintain optimal cognitive and physical performance. Understanding this neurobiological basis is essential for clinically addressing chronic energy depletion and lack of motivation.