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Central Command Override

Meaning

Central command override describes a physiological state where a powerful, often acute, homeostatic signal originating from higher brain centers, such as the hypothalamus or cortex, temporarily supersedes the normal, peripheral feedback mechanisms. This phenomenon is typically observed during periods of intense psychological stress, perceived threat, or extreme physical exertion, compelling the body to prioritize immediate survival functions. It represents the central nervous system’s capacity to dictate systemic function, bypassing the usual regulatory checks and balances of the peripheral endocrine system. Understanding this override is crucial for managing conditions driven by chronic stress and HPA axis dysregulation.