The Central Autonomic Network (CAN) is a distributed collection of interconnected brain regions that collectively regulate the autonomic nervous system’s control over visceral function and emotional state. This network includes key structures like the hypothalamus, amygdala, and brainstem nuclei, serving as the interface between higher-level cognitive and emotional processing and the body’s physiological systems. It is the master coordinator for internal equilibrium, integrating signals to maintain cardiovascular, respiratory, and endocrine homeostasis. Dysregulation within the CAN is strongly implicated in stress-related hormonal disorders.
Origin
The term is descriptive, combining “central,” referring to the brain and spinal cord, with “autonomic network,” highlighting the interconnected nature of the brain regions controlling involuntary functions. The understanding of this network developed as neuroscientific research moved beyond localized functions to recognize complex, integrated neural circuits.
Mechanism
The CAN operates by receiving afferent signals from the periphery and integrating them with descending commands from cortical areas. It generates efferent signals that travel via the sympathetic and parasympathetic branches of the autonomic nervous system to target organs. For example, in response to perceived stress, the CAN rapidly initiates the hypothalamic-pituitary-adrenal axis cascade while simultaneously adjusting heart rate and digestion, demonstrating its crucial role in hormonal and metabolic stress adaptation.
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