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Cellular Unresponsiveness Indicators

Meaning

Specific molecular or physiological markers detected clinically that signify a reduced or absent cellular response to an otherwise adequate concentration of a signaling molecule, such as a hormone or growth factor. These indicators, often involving post-receptor signaling defects or reduced receptor density, are the hallmarks of endocrine resistance syndromes. Identifying these indicators is vital for diagnosing conditions like insulin resistance or tissue-specific hormone hypo-responsiveness.