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Cellular Timekeeping Fidelity

Meaning

Cellular Timekeeping Fidelity refers to the precision and reliability with which individual cells maintain their internal 24-hour biological rhythm, or circadian clock. This metric assesses the accuracy of the molecular oscillation of core clock genes, such as CLOCK and BMAL1, within a cell. High fidelity indicates robust, consistent timing of gene expression and cellular processes, which is vital for optimal tissue function and metabolic health. Loss of fidelity is often associated with aging, chronic disease states, and hormonal dysregulation. Maintaining this precision is a fundamental aspect of systemic homeostasis and longevity.