Skip to main content

Cellular Thyroid Hormone Unresponsiveness

Meaning

Cellular Thyroid Hormone Unresponsiveness, often clinically termed Thyroid Hormone Resistance (THR), is a complex endocrine disorder where the body’s target tissues exhibit a diminished or impaired biological response to circulating thyroid hormones, despite those hormone levels being normal or elevated. This condition represents a defect in the hormone’s action at the cellular level, rather than a failure of the thyroid gland to produce the hormone. The resulting clinical picture is highly variable, presenting a spectrum of hypothyroid and euthyroid symptoms depending on the specific tissue affected by the signaling impairment.