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Cellular Signaling Variance

Meaning

Cellular signaling variance describes the inherent biological differences in how individual cells or tissues receive, process, and respond to external and internal molecular cues, such as hormones or growth factors. This variability arises from genetic polymorphisms, epigenetic modifications, and dynamic changes in receptor density or downstream signaling cascade components. Clinically, this variance is a key determinant of why individuals exhibit different physiological responses to the same hormonal stimulus or therapeutic intervention. Recognizing this differential responsiveness is essential for personalized medicine and achieving predictable clinical outcomes.