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Cellular Sensitivity Re-Sensitization

Meaning

Cellular sensitivity re-sensitization is a therapeutic and physiological objective aimed at restoring the responsiveness of cell receptors to their cognate signaling molecules, particularly hormones, after a period of desensitization or downregulation. The process is critical in managing conditions like insulin resistance, where target cells have become refractory to normal hormone levels. Successful re-sensitization enhances the efficacy of both endogenous and exogenous hormones. This restoration of signal transduction capacity is vital for maintaining metabolic homeostasis.