What is the Origin of Cellular Senescence Therapy?

This therapeutic concept is a direct product of modern gerontology and cellular biology research, specifically the discovery and characterization of the Senescence-Associated Secretory Phenotype (SASP). The term emerged with the development of senolytic agents, which are compounds designed to induce apoptosis specifically in senescent cells. It signifies a novel pharmacological strategy for age-related disease intervention.

What is the Mechanism of Cellular Senescence Therapy?

The primary mechanism involves administering senolytic compounds that disrupt the pro-survival pathways uniquely active in senescent cells, such as Bcl-2 or PI3K/Akt. This selective disruption triggers programmed cell death (apoptosis) in the dysfunctional cells, allowing the immune system to clear them without harming healthy, non-senescent cells. By removing these sources of chronic inflammation and tissue damage, the therapy aims to rejuvenate surrounding tissue function.

Cellular Senescence Therapy ∞ Area

Cellular Senescence Therapy

Meaning

Cellular Senescence Therapy is a specialized intervention aimed at selectively clearing or modifying senescent cells—cells that have ceased dividing but remain metabolically active, secreting pro-inflammatory factors. These “zombie cells” accumulate with age and contribute significantly to tissue dysfunction and chronic inflammation, a state known as inflammaging. The therapy seeks to reduce the overall senescent cell burden to improve tissue microenvironments and restore regenerative capacity. This represents a targeted approach to mitigating a core hallmark of biological aging.