What is the Origin of Cellular Senescence Protocols?

The development of these protocols stems directly from aging research identifying cellular senescence as a core mechanism contributing to age-related pathology across organ systems. Protocols often leverage compounds termed senolytics, developed to selectively target and destroy these persistent cells. The clinical translation focuses on reversing detrimental inflammatory signaling.

What is the Mechanism of Cellular Senescence Protocols?

The mechanism of action for many protocols involves the introduction of senolytic agents that exploit metabolic vulnerabilities unique to senescent cells, inducing programmed cell death. Additionally, protocols may incorporate hormonal adjustments, such as optimizing DHEA or growth hormone availability, which can suppress the pro-survival signaling that keeps senescent cells active. Clearing these cells restores the local microenvironment to a healthier, less catabolic state.

Cellular Senescence Protocols ∞ Area

Cellular Senescence Protocols

Meaning

Cellular Senescence Protocols are targeted clinical strategies designed to manage or eliminate senescent cells, which are dysfunctional cells that accumulate with age and secrete harmful pro-inflammatory molecules known as the SASP. Effective protocols aim to clear this cellular debris to restore healthy tissue paracrine signaling and mitigate chronic inflammation. This is a crucial intervention for optimizing tissue healthspan.