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Cellular Senescence Pathways

Meaning

Cellular Senescence Pathways describe the distinct, highly conserved molecular cascades that drive cells into a state of irreversible growth arrest, often while remaining metabolically active and secreting pro-inflammatory factors. In hormonal health, the accumulation of these senescent cells contributes significantly to tissue aging and the subsequent decline in endocrine gland function. Identifying these pathways is critical because their persistence contributes to systemic inflammation and metabolic dysfunction. We are looking beyond simple cell death to understand this state of permanent functional stagnation.