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Cellular Senescence Negation

Meaning

Cellular Senescence Negation is a biological and clinical objective focused on inhibiting or reversing the state of irreversible growth arrest that cells enter, known as senescence. Senescent cells accumulate with age and hormonal decline, secreting pro-inflammatory molecules that damage surrounding tissue and accelerate aging—a phenomenon termed the Senescence-Associated Secretory Phenotype (SASP). Negating this process is a key strategy in longevity medicine to preserve tissue function and reduce chronic inflammation.