What is the Origin of Cellular Senescence Modulation?

The foundational concept of cellular senescence was first described in the early 1960s by Leonard Hayflick, observing the finite division capacity of human cells. "Modulation" is a clinical term emphasizing the deliberate, targeted adjustment of this biological process, rather than simply observation. The practice is central to the emerging field of geroscience.

What is the Mechanism of Cellular Senescence Modulation?

The primary mechanism involves targeting the senescence-associated secretory phenotype (SASP) and selectively clearing senescent cells through agents known as senolytics. Hormonal pathways, particularly those related to growth factors and nutrient sensing (like mTOR and AMPK), are intimately linked to the initiation and progression of senescence. Modulating these signals helps restore cellular health and tissue function by reducing chronic, low-grade inflammation.

Cellular Senescence Modulation ∞ Area ∞ Library 2

Cellular Senescence Modulation

Meaning

Cellular Senescence Modulation is the clinical strategy focused on regulating the process where cells cease to divide but remain metabolically active, often secreting pro-inflammatory factors. This regulation aims to reduce the burden of senescent cells, frequently termed “zombie cells,” which accumulate with age and contribute to tissue dysfunction and chronic disease. Effective modulation is considered a core pillar of preventative and longevity medicine.