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Cellular Senescence Mitigation Strategies

Meaning

Cellular senescence mitigation strategies encompass targeted clinical or lifestyle approaches designed to reduce the burden of non-proliferative, aging cells that accumulate in tissues over time. These senescent cells secrete pro-inflammatory factors, known as the Senescence-Associated Secretory Phenotype (SASP), which negatively impact local tissue microenvironments and systemic endocrine signaling. Effective mitigation aims to preserve tissue function and improve overall physiological resilience. This is a proactive approach to maintaining tissue vitality.