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Cellular Senescence Markers

Meaning

Cellular Senescence Markers are specific molecular and phenotypic indicators present in cells that have entered a state of irreversible growth arrest, a key process in biological aging. These markers include the presence of Senescence-Associated Secretory Phenotype (SASP) factors, elevated p16INK4a protein expression, and the characteristic accumulation of lipofuscin. Identifying and quantifying these markers provides a tangible assessment of the body’s biological age and accumulated cellular burden. Clinically, they serve as targets for interventions aimed at clearing senescent cells to improve tissue function.