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Cellular Senescence Interception

Meaning

Cellular senescence interception is a targeted clinical strategy aimed at mitigating the accumulation of senescent cells, which are aged cells that cease dividing but remain metabolically active and secrete pro-inflammatory molecules. These “zombie cells” contribute significantly to chronic inflammation, tissue dysfunction, and age-related decline, including endocrine gland impairment. Interception involves the use of senolytic and senomorphic agents to either clear these dysfunctional cells or suppress their harmful secretory phenotype. This intervention is a core component of advanced longevity medicine and hormonal health preservation.