What is the Origin of Cellular Senescence Endocrinology?

The concept is a modern synthesis derived from the fields of cellular biology, aging research (geroscience), and endocrinology. Cellular senescence was first described in the early 1960s, but its deep connection to systemic hormonal regulation has become a major focus of research in the twenty-first century. This integrated approach acknowledges that hormonal shifts are not merely consequences of aging but also drivers of the senescent state and its clinical manifestations.

What is the Mechanism of Cellular Senescence Endocrinology?

Hormonal decline, such as the reduction in sex steroids or growth hormone, can impair cellular repair mechanisms and increase susceptibility to DNA damage, thereby promoting senescence. Senescent cells, in turn, secrete pro-inflammatory cytokines, chemokines, and proteases, collectively known as SASP, which disrupt paracrine and endocrine signaling throughout the body. This creates a self-perpetuating cycle of inflammation, hormonal dysregulation, and accelerated biological aging.

Cellular Senescence Endocrinology ∞ Area

Cellular Senescence Endocrinology

Meaning

A specialized area of study focusing on the complex interplay between the endocrine system and cellular senescence, which is the state of irreversible cell cycle arrest. This field investigates how hormonal changes associated with aging contribute to the accumulation of senescent cells and, conversely, how the senescence-associated secretory phenotype (SASP) impacts endocrine function and systemic health. It represents a critical bridge between gerontology and endocrinology, seeking to understand age-related decline.