Cellular Senescence Countermeasures are therapeutic and lifestyle interventions specifically designed to eliminate or neutralize senescent cells, which are metabolically active but non-dividing cells that accumulate with age and secrete pro-inflammatory factors. These countermeasures aim to reduce the systemic burden of the Senescence-Associated Secretory Phenotype (SASP), thereby alleviating chronic inflammation and restoring tissue regenerative capacity. This clinical focus is vital for maintaining youthful tissue function and preventing age-related hormonal decline.
Origin
The concept originates from geroscience, following the identification of cellular senescence as a fundamental hallmark of aging and a primary driver of age-related pathology. The development of ‘senolytic’ and ‘senomorphic’ agents provided the tangible basis for this clinical strategy. Understanding the role of senescent cells offers a precise target for improving healthspan.
Mechanism
The primary mechanism involves using senolytic compounds, which selectively induce apoptosis in senescent cells by targeting their pro-survival pathways. Alternatively, senomorphic agents modulate the SASP, preventing senescent cells from releasing harmful inflammatory cytokines and proteases into the local tissue microenvironment. By clearing these dysfunctional cells, the countermeasures effectively reduce systemic inflammaging, improving stem cell function and enhancing the responsiveness of endocrine tissues.
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