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Cellular Senescence Counteraction

Meaning

Cellular Senescence Counteraction is a sophisticated therapeutic strategy aimed at inhibiting the accumulation of senescent cells, which are cells that have permanently exited the cell cycle but remain metabolically active and secrete pro-inflammatory factors. This process is a major contributor to tissue dysfunction and systemic aging, often referred to as the senescence-associated secretory phenotype (SASP). The goal of counteraction is to either eliminate these dysfunctional cells, a process called senolysis, or to modify their destructive secretory profile, known as senomorphics. Successfully managing senescent cell burden is a critical frontier in extending healthspan.