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Cellular Senescence Biomarkers

Meaning

Cellular senescence biomarkers are specific molecular and morphological indicators used to identify cells that have entered a state of irreversible growth arrest while remaining metabolically active. These senescent cells, often accumulating with chronological aging, secrete a pro-inflammatory mixture of molecules known as the Senescence-Associated Secretory Phenotype (SASP). Clinical assessment of these biomarkers, such as p16INK4a, senescence-associated beta-galactosidase (SA-β-gal), and specific SASP components, provides quantifiable insight into biological aging and its impact on tissue function. Monitoring these markers is increasingly relevant in longevity and hormonal health interventions.