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Cellular Senescence Assessment

Meaning

Cellular Senescence Assessment is the clinical methodology used to quantify the burden of aged, non-proliferating cells within tissues that have entered a stable growth arrest state. These senescent cells accumulate with age and secrete pro-inflammatory factors, often referred to as the Senescence-Associated Secretory Phenotype (SASP). Accurate assessment is crucial because this cellular burden directly correlates with systemic dysfunction and compromised hormonal signaling integrity. Identifying this load provides a direct measure of biological aging at the tissue level.